The influence of catalyst in reaction 10466-61-2

As far as I know, this compound(10466-61-2)Synthetic Route of C6H15ClN2O can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Synthetic Route of C6H15ClN2O. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Peptide synthesis with modified trypsin.

The authors have studied the relative abilities of native trypsin and its ethylene glycol bis(succinimidyl succinate)-modified derivative (EG-trypsin) as catalysts in the kinetically controlled synthesis of short peptides in acetonitrile-based and aqueous (borate) media. For example, PhCO-Arg-Leu-NH2 was synthesized from PhCO-Arg-OEt·HCl and H-Leu-NH2·HCl using both native and EG-trypsin in 95% acetonitrile at 4° C. The yield for the dipeptide was 94% with EG-trypsin after 6 h of reaction time, whereas the same yield was obtained after 24 h of reaction time with the native trypsin. EG-trypsin enabled maximum product yield more rapidly than native trypsin in the acetonitrile media; opposite was true in borate buffer.

As far as I know, this compound(10466-61-2)Synthetic Route of C6H15ClN2O can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare