The influence of catalyst in reaction 43142-76-3

Here is just a brief introduction to this compound(43142-76-3)Category: chiral-catalyst, more information about the compound(Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate) is in the article, you can click the link below.

Category: chiral-catalyst. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate, is researched, Molecular C12H10ClNO3, CAS is 43142-76-3, about Design of C3-Alkenyl-Substituted 2-Indolylmethanols for Catalytic Asymmetric Interrupted Nazarov-Type Cyclization.

The C3-alkenyl-substituted 2-indolylmethanols were designed as a new class of substrates for catalytic asym. interrupted Nazarov-type cyclizations. In the presence of a chiral phosphoric acid as a mild chiral Bronsted acid, the interrupted Nazarov-type cyclization of C3-alkenyl-substituted 2-indolylmethanols I (R1 = Ph, 4-ClC6H4, 2-FC6H4, etc.; R2 = Ph, 3-FC6H4, 3-MeC6H4; R3 = H, Cl, Br, MeO) with nucleophiles R4H (R4 = 3-indolyl, 2-hydroxy-1-naphthyl, etc.) occurred smoothly to construct cyclopenta[b]indole frameworks II with generally excellent diastereo- and enantioselectivities (up to >95:5 dr, >99% ee).

Here is just a brief introduction to this compound(43142-76-3)Category: chiral-catalyst, more information about the compound(Ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate) is in the article, you can click the link below.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare