The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: H-Leu-NH2.HCl( cas:10466-61-2 ) is researched.Safety of H-Leu-NH2.HCl.Bepary, Sukumar; Youn, In Kwon; Lim, Hee-Jong; Lee, Ge Hyeong published the article 《Diversified Aminohydantoins from Ureas and Thioureas Tethered to Amides》 about this compound( cas:10466-61-2 ) in European Journal of Organic Chemistry. Keywords: thiourea urea tethered amide preparation intramol cyclization; iminohydantoin aminoimidazolone preparation reaction mechanism tautomer; carbodiimide iminium ion intermediate. Let’s learn more about this compound (cas:10466-61-2).
Intramol. cyclization of thioureas or ureas tethered to amides afforded 2-iminohydantoins and 2-amino-1H-imidazol-4(5H)-ones in very high yields (87-100%) regardless of the substituent (alkyls or aryls). This reaction proceeds through carbodiimides and iminium ions as intermediates. Among the reagents used to generate the carbodiimides, CBr4/Ph3P, CCl4/Ph3P, O,O’-bis(2′-pyridyl)thiocarbonate, and HgO were investigated.
After consulting a lot of data, we found that this compound(10466-61-2)Safety of H-Leu-NH2.HCl can be used in many types of reactions. And in most cases, this compound has more advantages.