Synthetic Route of C6H15ClN2O. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about α-Chymotrypsin-catalyzed peptide synthesis using activated esters as acyl donors. Author is Miyazawa, Toshifumi; Nakajo, Shin’ichi; Nishikawa, Miyako; Imagawa, Kiwamu; Yanagihara, Ryoji; Yamada, Takashi.
The coupling efficiency in α-chymotrypsin-catalyzed peptide synthesis is greatly improved by the use of activated esters such as the 2,2,2-trifluoroethyl ester as the acyl donor instead of the conventional Me ester. For example, Z-Phe-Leu-NH2 is obtained in 98% yield when Z-Phe-OCH2CF3 (along with H-Leu-NH2) is used as the reactant instead of Z-Phe-OMe, which leads to a yield of 31% for the dipeptide. This approach is useful for the incorporation of non-protein amino acids into peptides.
《α-Chymotrypsin-catalyzed peptide synthesis using activated esters as acyl donors》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(H-Leu-NH2.HCl)Synthetic Route of C6H15ClN2O.