Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Hong, Haoran, once mentioned the application of 6381-59-5, Name is Potassium sodium tartrate tetrahydrate, molecular formula is C4H12KNaO10, molecular weight is 282.22, MDL number is MFCD00150989, category is chiral-catalyst. Now introduce a scientific discovery about this category, SDS of cas: 6381-59-5.
The trifluoromethylthio group is significant in drug design for its high stability, electronegativity, and lipophilicity. Herein, a series of indenone structures containing the SCF3 group and an adjacent chiral quaternary stereocenter were synthesized by an asymmetric Michael addition reaction using an ion pair catalyst derived from amino acids. The desired products were obtained in excellent yields (up to 98%) and good to high stereoselectivities (up to 97% ee and >20:1 dr).
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Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare