The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-1-{(S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl]phosphino]-ferrocenyl}ethyldicyclohexylphosphine( cas:849923-15-5 ) is researched.Application In Synthesis of (S)-1-{(S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl]phosphino]-ferrocenyl}ethyldicyclohexylphosphine.Ibrahim, Ahmad A.; Wei, Pei-Hsun; Harzmann, Gero D.; Kerrigan, Nessan J. published the article 《Josiphos-Catalyzed Asymmetric Homodimerization of Ketoketenes》 about this compound( cas:849923-15-5 ) in Journal of Organic Chemistry. Keywords: ketoketene Josiphos asym homodimerization; beta lactone ketoketene dimer stereoselective preparation; Josiphos asym homodimerization chiral phosphine catalyst. Let’s learn more about this compound (cas:849923-15-5).
In this paper the development of a chiral phosphine-catalyzed homodimerization of ketoketenes that provides access to a variety of highly substituted ketoketene dimer β-lactones, e.g., I, is reported. The Josiphos catalytic system displays good to excellent enantioselectivity (up to 96% ee). Ring-opening reactions of the enantioenriched ketoketene dimers were also carried out to access 1,3-diketones, enol esters, and β-hydroxyketones with good diastereoselectivity.
《Josiphos-Catalyzed Asymmetric Homodimerization of Ketoketenes》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((S)-1-{(S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl]phosphino]-ferrocenyl}ethyldicyclohexylphosphine)Application In Synthesis of (S)-1-{(S)-2-[Bis[3,5-bis(trifluoromethyl)phenyl]phosphino]-ferrocenyl}ethyldicyclohexylphosphine.