Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 6645-46-1, Name is (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride, SMILES is C[N+](C)(C)C[C@H](O)CC(O)=O.[Cl-], belongs to chiral-catalyst compound. In a document, author is Dou, Zhe, introduce the new discover, Recommanded Product: 6645-46-1.
A novel carboxylesterase AcEst1 was identified from Acinetobacter sp. JNU9335 with high efficiency in the biosynthesis of chiral precursor of Edoxaban through kinetic resolution of methyl 3-cyclohexene-1-carboxylate (CHCM). Sequence analysis revealed AcEst1 belongs to family IV of esterolytic enzymes and exhibits < 40% identities with known carboxylesterases. The optimum pH and temperature of recombinant AcEst1 are 8.0 and 40 degrees C. Substrate spectrum analysis indicated that AcEst1 prefers substrates with short acyl and alcohol groups. AcEst1 was highly active in the hydrolysis of CHCM with k(cat) of 1153 s(-1) and displayed high substrate tolerance. As much as 2.0 M (280 g.L-1) CHCM could be enantioselectively hydrolyzed into (S)-CHCM by merely 0.08 g.L-1 AcEst1 with ee(s) of > 99% (S) and substrate to catalyst ratio (S/C) of 3500 g.g(-1). These results indicate that the novel AcEst1 is a promising biocatalyst in the synthesis of chiral carboxylic acids.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 6645-46-1 is helpful to your research. Recommanded Product: 6645-46-1.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare