A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 80657-57-4, Name is (S)-Methyl 3-hydroxy-2-methylpropanoate, molecular formula is C5H10O3. In an article, author is Zhu, Wen-Run,once mentioned of 80657-57-4, Formula: C5H10O3.
A catalytic asymmetric oxa-1,3-dipolar cycloaddition of ketones with trifluoroethylamine-derived azomethine ylides has been developed using cinchona-derived bifunctional thiourea catalysts. This protocol provides an efficient methodology for the facile synthesis of chiral CF3-containing oxazolidines with moderate to excellent yields, excellent diastereoselectivities and enantioselectivities (58-98% yields, up to >20 : 1 dr and 98% ee). Remarkably, these oxazolidines could be facilely converted to CF3-containing 1,2-amino alcohols with vicinal stereogenic centers, which is a privileged structural motif in medicinal chemistry.
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Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare