Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 22468-26-4, is researched, SMILESS is O=C(O)C1=NC=CC(O)=C1, Molecular C6H5NO3Journal, Comparative Study, Article, Research Support, U.S. Gov’t, P.H.S., Brain Research called Structure-function relationships for kynurenic acid analogs at excitatory pathways in the rat hippocampal slice, Author is Robinson, Michael B.; Schulte, Marvin K.; Freund, Ronald K.; Johnson, Rodney L.; Koerner, James F., the main research direction is kynurenate structure function hippocampus.COA of Formula: C6H5NO3.
Eight kynurenic acid analogs were bath-applied to rat hippocampal slices while recording extracellular synaptic field potentials, and the potencies of these analogs for inhibition of these responses were compared to that of kynurenic acid [492-27-3]. Quinaldic acid [93-10-7], 4-hydroxyquinoline [611-36-9], 4-hydroxypicolinic acid [22468-26-4], L-kynurenine [2922-83-0], and picolinic acid [98-98-6] inhibited evoked field potentials, but were at least 15-fold less potent than kynurenic acid in all pathways tested. Xanthurenic acid [59-00-7] was inactive in the pathways tested. Quinolinic acid [89-00-9] and dipicolinic acid [499-83-2] showed signs of agonist activity with half-max ID’s of approx. 400 μM and 2500 μM, resp. Evidently, the 2-carboxy group and the 4-hydroxy moiety are essential for the antagonist activity exhibited by kynurenate. The unsubstituted 2nd aromatic ring greatly enhances the affinity of kynurenate for these receptors, and substitution in at least 1 position on this aromatic ring abolishes activity.
Different reactions of this compound(4-Hydroxypicolinic acid)COA of Formula: C6H5NO3 require different conditions, so the reaction conditions are very important.