Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 145-42-6, Name is Monosodium taurocholate, molecular formula is , belongs to chiral-catalyst compound. In a document, author is Rao, D. H. Sreenivasa, Recommanded Product: Monosodium taurocholate.
Enantiopure beta-nitroalcohols are versatile intermediates used in the synthesis of important pharmaceuticals and chiral synthons. In this article, immobilizedArabidopsis thalianaHNL (AtHNL)-catalyzed preparation of (S)-beta-nitroalcohols from their racemic mixtures via retro-Henry reaction was studied.AtHNL used in biocatalysis was immobilized by physical adsorption in inexpensive celite (R) 545. Under optimized biocatalytic conditions, the total turnover number of the catalyst has improved 2.3-fold for (S)-2-nitro-1-phenylethanol (NPE) synthesis, than free enzyme catalysis. This study reported for the first time celite-AtHNL-catalyzed retro-Henry reaction at low pH. At pH 4.5 and 5.0, 62% ee and 41% conversion, and 97% ee and 42% conversion of (S)-NPE were obtained respectively, while the free enzyme inactivates at pH < 5.0. The increased catalytic efficiency and pH stability of the catalyst could be possibly due to increased stability ofAtHNL by immobilization. A dozen of racemic beta-nitroalcohols were converted into their corresponding (S)-beta-nitroalcohols using this reaction; among them, eight were not tested earlier. The immobilized enzyme has showed broad substrate selectivity in the retro-Henry reaction, and products were obtained up to 98.5% ee. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 145-42-6, in my other articles. Recommanded Product: Monosodium taurocholate.
Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare