Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 10466-61-2, is researched, SMILESS is N[C@@H](CC(C)C)C(N)=O.[H]Cl, Molecular C6H15ClN2OJournal, Journal of the Chemical Society, Perkin Transactions 1 called Broadening of the substrate tolerance of α-chymotrypsin by using the carbamoylmethyl ester as an acyl donor in kinetically controlled peptide synthesis, Author is Miyazawa, Toshifumi; Tanaka, Kayoko; Ensatsu, Eiichi; Yanagihara, Ryoji; Yamada, Takashi, the main research direction is chymotrypsin catalyzed peptide coupling carbamoylmethyl alanine.COA of Formula: C6H15ClN2O.
In the kinetically controlled approach of peptide synthesis mediated by α-chymotrypsin, the broadening of the protease’s substrate tolerance is achieved by switching the acyl donor from the conventional Me ester to the carbamoylmethyl ester. Thus, as a typical example, the extremely low coupling efficiency obtained by employing the Me ester of an inherently poor amino acid substrate, Ala, is significantly improved by the use of this particular ester. Its ameliorating effect is observed also in the couplings of other amino acid residues such as Gly and Ser as carboxy components.
This compound(H-Leu-NH2.HCl)COA of Formula: C6H15ClN2O was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.