The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: H-Leu-NH2.HCl(SMILESS: N[C@@H](CC(C)C)C(N)=O.[H]Cl,cas:10466-61-2) is researched.COA of Formula: C9H16O2. The article 《Ultrasound and ZnCl2 promoted synthesis of phthaloyl derivatives of α-amino carboxamides》 in relation to this compound, is published in Synthesis. Let’s take a look at the latest research on this compound (cas:10466-61-2).
A new, one-step and racemization-free synthesis of phthaloyl derivatives of α-amino carboxamides is described. Under ultrasound, α-amino carboxamides and dipeptide derivatives react with monomethyl phthalate in the presence of BOP, ZnCl2 and i-Pr2NEt to afford the corresponding Nu-phthaloyl α-amino carboxamides or dipeptides in good to excellent yields. Cyclization of the intermediate Nu-[(o-methoxycarbonyl)benzoyl]amino carboxamides to the desired products was very slow when the reaction was conducted either in the absence of ZnCl2 and/or without sonication, but the process was greatly accelerated when both ZnCl2 and ultrasound were used.
There is still a lot of research devoted to this compound(SMILES：N[C@@H](CC(C)C)C(N)=O.[H]Cl)Recommanded Product: H-Leu-NH2.HCl, and with the development of science, more effects of this compound(10466-61-2) can be discovered.