Reference of H-Leu-NH2.HCl. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about New insights into the synthesis and characterization of 2-methoxy-3-alkylpyrazines and their deuterated isotopologues. Author is Schmarr, H.-G.; Sang, W.; Ganss, S.; Koschinski, S.; Meusinger, R..
A previously described synthetic route for preparation of 2-methoxy-3-alkylpyrazines (MPs) based on condensation of glyoxal with an α-amino acid amide, followed by methylation with iodomethane yields 3-alkyl-1-methyl-1H-pyrazin-2-ones (N-Me derivatives), rather than the expected 2-methoxy-3-alkylpyrazines (O-Me derivatives). Despite similar NMR and mass spectral properties, gas chromatog. retention indexes differ significantly, indicating chem. difference. With the example of 3-sec-butyl-1-methyl-1H-pyrazin-2-one and its 3-sec-butyl-1-[2H3]methyl-1H-pyrazin-2-one isotopolog, the position of the Me group introduced could be assigned unambiguously, using heteronuclear multiple bond correlation NMR experiments For future characterization, the spectroscopic (NMR, EI+MS) as well as GC retention index data on two stationary phases of the most aroma relevant MPs and their deuterated isotopologues are summarized. Copyright © 2011 John Wiley & Sons, Ltd.
As far as I know, this compound(10466-61-2)Reference of H-Leu-NH2.HCl can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.